Use of a physiologically based pharmacokinetic model to simulate drug–drug interactions between antineoplastic and antiretroviral drugs
نویسندگان
چکیده
منابع مشابه
Interactions between antineoplastic agents and ARV drugs.
Drug-drug interactions can be a serious complication of taking multiple medications and account for 3% to 5% of all in-hospital medication errors.1 The consequences of drug interactions vary, ranging from excessive blood levels causing drug toxicities to therapeutic failures following sub-optimal blood levels. While the advent of highly active antiretroviral therapy (HAART) for the treatment of...
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Physiologically based pharmacokinetic models are being used in an increasing number of different areas. However, they are perceived as complex, data hungry, resource intensive, and time consuming. In addition, model validation and verification are hindered by the relative complexity of the equations. To begin to address these issues a web application called MEGen for the rapid construction and ...
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Drug interactions with digoxin are important because of this agent's narrow therapeutic index. Among the drugs that can decrease digoxin bioavailability are cholestyramine, antacid gels, kaolin-pectate, certain antimicrobial drugs and cancer chemotherapeutic agents. In selected patients, antibiotics may enhance digoxin bioavailability by eliminating intestinal flora that metabolize digoxin. Ant...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2016
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkw485